发明名称 N-SUBSTITUTED-5-PHENYL-4,1-BENZOXAZEPIN-2(3H)-ONES HAVING THERAPEUTIC UTILITY
摘要 Compounds of the formula <CHEM> wherein R1 is cyclopropylmethyl, 2-phenylethyl, aminoalkyl, cycloaminoalkyl, optionally ring-substituted phenoxyalkyl, optionally ring-substituted phenylthioalkyl, optionally ring-substituted phenylsulphinylalkyl, optionally ring-substituted phenylsulphonylalkyl, cycloalkoxyalkyl, optionally ring-substituted phenylalkyl, hydroxyalkyl, alkoxyalkyl or phthalimidoalkyl; R2 is H, alkyl or phenyl; and Y1 is H, Cl, Br, F, MO2 or CF3, can have utility as inhibitors of phospholipase A2 and thus as inhibitors of arachidonic acid cascade biosynthesis.
申请公布号 DE3471101(D1) 申请公布日期 1988.06.16
申请号 DE19843471101 申请日期 1984.11.12
申请人 THE UPJOHN COMPANY 发明人 WALLACH, DONALD PINNY;SZMUSZKOVICZ, JACOB;AYER, DONALD EMORY
分类号 C07D267/14;C07D413/06;(IPC1-7):C07D267/14;A61K31/55 主分类号 C07D267/14
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