MITOMYCIN ANALOGUES

摘要

Compounds of the general formula: {wherein X represents a group [in which R3 represents a cycloalkyl or straight chain or branched alkyl group having up to 7 carbon atoms, said alkyl or cycloalkyl group optionally carrying 1 to 3 amino groups and/or 1 to 3 hydroxyl groups; a -(CH2)nCO2R4 group (in which n is the integer 1, 2 or3, and R4 represents a methyl or ethyl group); a pyridyl group; or a group of the formula: and R1 and R2 which may be the same or different, each represents a hydrogen atom or a methyl group, and indicates alpha or beta bonding] possess good antibacterial and anti-tumor activity. The compounds of formula I may be prepared for example by reaction of mitomycin A, B, F or J with the appropriate amine.