发明名称 |
DELIVERY DEVICE FOR ZERO-ORDER RELEASE OF AN ACTIVE PRINCIPLE IN A FLUID PHASE |
摘要 |
<p>A delivery device for zero-order release of an active principle into a dissolution fluid includes a reservoir consisting of a solid matrix of a homogeneous mixture of a polymer material, at least a portion of the active principle and an additive soluble in the dissolution fluid with negative heat of solution, a coating on the solid matrix-type reservoir of a first, release rate-controlling insoluble membrane which modulates the active principle release according to the desired kinetics; and a second, protective membrane on the release rate-con-trolling membrane of a soluble polymer material.</p> |
申请公布号 |
CA1235654(A) |
申请公布日期 |
1988.04.26 |
申请号 |
CA19850487552 |
申请日期 |
1985.07.25 |
申请人 |
SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. |
发明人 |
COLOMBO, PAOLO;CONTE, UBALDO;REINER, ALBERTO |
分类号 |
A61K9/22;A61K9/66;(IPC1-7):A61K9/22 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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