发明名称 |
IMPROVEMENTS RELATING TO CONTROL OF NEOPLASTIC TISSUE GROWTH |
摘要 |
Compounds of the general formula: <CHEM> wherein R is H, an acyl group or a hydrocarbyl group containing up to 6 carbon atoms, have cytotoxic activity against several tumours. The 4-hydroxylamino compound can be obtained directly from the corresponding 2,4-dinitro compound by selective chemical reduction or by the action of a nitroreductase obtainable from Walker tumour cells. The 2,4-dinitro compound is substantially devoid of cytotoxic activity except in relation to Walker tumour cells and hence can act as a prodrug in regimes where a prodrug is localised in vivo in the regions of a tumour to be treated and is then activated to the cytotoxic 4-hydroxylamino compound under the influence of the enzyme. |
申请公布号 |
GB8804068(D0) |
申请公布日期 |
1988.03.23 |
申请号 |
GB19880004068 |
申请日期 |
1988.02.22 |
申请人 |
ROBERTS, J R;KNOX, R J;FRIEDLOS, F |
发明人 |
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分类号 |
A61K31/395;A61K31/396;A61K38/44;A61P35/00;C07D203/08;C07D203/14;C12N9/02;C12P17/10 |
主分类号 |
A61K31/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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