| 摘要 |
<p>A method of making a cytotoxic lectin complex having diminished non-specific toxicity by immobilizing on a solid support by a covalent linkage a ligand which has specific binding capacity for the oligosaccharide-binding sites of lectin to form a probe, binding the lectin to the ligand of the probe, and thereafter covalently bonding the lectin to the ligand to form a complex. The complex may then be severed from the solid support provided the first covalent linkage is cleavable, and may be covalently bonded to a monoclonal antibody.</p> |
