发明名称 |
PROCESS FOR PRODUCING DAUNORUBICIN AND DOXORUBICIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
摘要 |
<p><IMAGE> The anthracycline glycosides I (X = H or OH, R1 = H or CH3, R2 = H or OCH3, R3 = H or OCH3, R2 = R3) and their pharmaceutically acceptable acid addition salts have antitumour properties. They are prepared from 4-demothoxy-daunomycinone or 2,3-dimethyl-4-methoxy-daunomycinone by condensation with an appropriate N-protected hexopyranosyl chloride and removal of the protecting group and, in the case X = OH, conversion of the 9-acetyl group to a 9-hydroxyacetyl group.</p> |
申请公布号 |
HU192784(B) |
申请公布日期 |
1987.07.28 |
申请号 |
HU19830000240 |
申请日期 |
1983.01.25 |
申请人 |
FARMITALIA ERBA |
发明人 |
PENCO,SERGIO;FRANCHI,GIULIANO;ARCAMONE,FEDERICO;CASAZZA,ANNA M. |
分类号 |
C07H15/24;A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61P35/00;A61P35/02;C07H15/252;(IPC1-7):C07H15/24 |
主分类号 |
C07H15/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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