发明名称 |
Laevorotatory antipode of moprolol as an antihypertensive |
摘要 |
This invention relates to a process for the separation of moprolol into its two optical antipodes, substantially characterized by the fact of salifying racemic moprolol with L(+)glutamic acid; treating the thus obtained mixture of diastereoisomeric salts with a water/alcohol mixture, in this way separating the L(+)glutamate insoluble salt of (+)moprolol; treating the resultant mother liquors which contain in solution the L(+)glutamate salt of (-)moprolol with a base so as to separate the laevorotatory isomer of crystalline moprolol, which finally undergoes a purification. The invention also relates to a pharmaceutical composition containing said laevorotatoryisomer of moprolol.
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申请公布号 |
US4683245(A) |
申请公布日期 |
1987.07.28 |
申请号 |
US19820434362 |
申请日期 |
1982.10.14 |
申请人 |
SIMES S.P.A. SOCIETA ITALIANA MEDICINALI E SINTETICI |
发明人 |
FERRARI, GIORGIO;VECCHIETTI, VITTORIO |
分类号 |
A61K31/13;A61K;A61K31/05;A61K31/135;A61P25/02;C07B31/00;C07B57/00;C07C39/06;C07C67/00;C07C213/00;C07C217/34;(IPC1-7):A61K31/135 |
主分类号 |
A61K31/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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