摘要 |
1-cyclo propyl-6-fluono-1,4-dihydro-4-oxo-7-(alkyl-1-piperazinyl) quinoline-3-carboxylate (I) [R'=hydrogen, C1-12 alkyl;R2, R3,R4, R5=hydrogen, C1-4 alkyl! is prepd. for use as an antibiotic. 2.8g of 7-chlono-1-cyclopropyl-6-fluoro-1, and hydro-4oxoquinoline 5.1g of 2- methyl piperazine is mixed in 6ml of dimethyl sulfoxide and this mixt. is stirred at 140≦̸C for 2 hrs to give 1.8g of 1-cyclo propyl-6- fluoro-1,4-dihydro-4-oxo-7-(3methyl-1-piperazinyl) quinoline-3- carboxylate semihydrate.
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