PROCESS FOR PREPARING 2-(N-SUBSTITUTED GUANIDINO)-4-HETEROARYLTHIAZOLES

摘要

Thiazole derivs. of formula (I) and their acid addn. salts are new. (X=NH; and Y=CH or N; or X=S; and Y=CH; R1=C4-10 alkyl, C6H3(R3)2 or (R3)2Ar(CH2)n; n=1-4; each R3=H, F, Cl, Br, I, Me, MeO, NO2, NH2, OH, CN, COOR5 or OCOR5; R5=C1-3alkyl; Ar=phenyl, naphthyl, furyl, thienyl, pyridyl, pyrimidinyl, thiazolyl or imidazolyl residue; R2=H or alkyl; R4=H, NH2 or CH2OH). (I) are useful as antisecretory agents, histamine-H2 acceptor antagonists and/or inhibitors of ethanol induced gastric ulcerations.