| 摘要 |
A therapeutic composition of antiinflammatory, analgesic and antipyretic activity comprises as its active principle, at least one component of the general formula: <IMAGE> in which R is a linear or branched alkyl radical containing 1-18 C atoms or a phenylalkylene in which the alkylene chain contains 1-6 C atoms; R1 is H, an aliphatic acyl radical containing 1-6 C atoms or an aromatic acyl radical; R2 is H, an aliphatic acyl radical containing 1-6 C atoms, or an aromatic acyl radical, or the radicals R2 together form an isopropylidene chain; and N is 0 or 1, or an acid additive salt of a compound of formula (I) in which R' is hydrogen. Various methods of preparing compounds of formula (I) are disclosed including a method of preparing 5'-deoxy-5'-methylthiodenosine by hydrolysing a concentrated aqueous solution of S-adenosyl-methionine by heating under reflux, neutralising the reaction mixture and cooling it to separate the 5'-deoxy-5'-methylthioadenosine formed. |
