| 摘要 |
<p>A method of covalently binding, in aqueous solution, a compound containing at least one nucleophilic group chosen among amines, alcohols or thiols, with amines as preferred group, to an amino and/or hydroxyl group containing polymer. The method is characterized of: (A) (i) that the amine nitrogen and oxygen of the hydroxyl group of the polymer, respectively, is bound to a saturated carbon atom and that the amino groups are primary or secondary; and (ii) that the polymer exhibit a great number of groups containing alkene groups; and (B) (i) that in aqueous solution and at pH 4-8 reacting the polymer with HOX, where X is chlorine, bromine or iodine, so that the double bonds of the alkene groups are transferred to oxirane, vicinal dihalid or halohydrin; and (ii) that reacting the formed oxirane-, vicinal dihalid- or halohydrin group with said compound which exhibit at least one nucleophilic group during conditions such as the compound binds to one of the carbon atoms which is part of the oxirane-, dihalid- or halohydrin structure.</p> |
