发明名称 |
Allosteric inhibitors and activators of pyruvate kinase |
摘要 |
Chemical structures have been identified which allosterically modify pyrvate kinase and either inhibit or activate enzymatic activity. These compounds can be used as pharmaceuticals in the treatment of a wide variety of diseases and disorders where influencing metabolic processes is beneficial, such as the glycolytic pathway, all pathways which use ATP as an energy source, and all pathways which involve 2,3-diphosphoglycerate. |
申请公布号 |
AU3109099(A) |
申请公布日期 |
1999.10.18 |
申请号 |
AU19990031090 |
申请日期 |
1999.03.23 |
申请人 |
ALLOS THERAPEUTICS, INC.;VIRGINIA COMMONWEALTH UNIVERSITY |
发明人 |
DONALD ABRAHAM;RICHMOND DANSO-DANQUAH;TELIH BOYIRI;IJEOMA NNAMANI;CHANGQUING WANG;MICHAEL GERBER;STEPHEN HOFFMAN;GAJANAN JOSHI |
分类号 |
A61K31/00;A61K31/192;A61K31/196;A61K31/198;A61K31/277;A61K31/325;A61K31/4409 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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