| 摘要 |
Novel phosphoaziridines of the formula: <IMAGE> wherein Z is oxygen or sulfur, R1 is independently at each occurrence H or -CH3, R2 is independently at each occurrence -CH3 or nitrophenyl R5; R3 is -NHR4, -OR4, -SR4 or <IMAGE> where R4 is a radical containing up to 30 atoms including at least one amine, ester, ether, alkyl, substituted alkyl, hydrogen, phenyl, substituted phenyl, carbamate, heterocyclic ring or R5 group; provided that, when R4 contains and R5 group, R4 has an alkyl group between the phosphorous and the R5 group; and R5 is a radical containing and electron affinic group comprising a quinone, or a heterocyclic or phenyl ring directly connected to a radical selected from the group consisting of nitro, nitroso, sulfinyl, sulfoxine, and N-oxide; provided that the compound contains at least one R5 radical and provided that when R1 is H, the R2 group on the same ring is R5; and the method for using the above compounds for the treatment of tumors.
|
