Indole-2-alkanoic acids and their use as prostaglandin antagonists.

摘要

Compounds of the formula I <CHEM> where R<1> is H or alkyl of 1 to 6 carbons or R<1> and R<8> taken together form a group (CH2)v wherein v is 1 to 7; <CHEM> where each R<8> is independently H, OH, C1 to C4-O alkyl or alkyl of 1 to 4 carbons; or an R<1> and an R<8> taken together form a group (CH2)v wherein v is 1 to 7, R<9> is COOR<1>; CH2OH; CHO; tetrazole; NHSO2R<1><0> wherein R<1><0> is OH, alkyl or alkoxy or 1 to 6 carbons, perhaloalkyl of 1 to 6 carbons, phenyl or phenyl substituted by alkyl or alkoxy groups of 1 to 3 carbons, halogen, hydroxy, COOH, CN, formyl or acyl of 1 to 6 carbons; CONHSO2R<1><0>; hydroxymethylketone; CN; or CON(R<8>)2; X is O; S; SO; SO2; NR<1><1> wherein R<1><1> is H, alkyl of 1 to 6 carbons, acyl of 1 to 6 carbons, CN; CR<1>R<8>; or the unit <CHEM> wherein the dotted line represents an optical triple bond and in which the R<1> and R<8> substituents are absent when a triple bond is present; r and q are each independently 0 to 5 and p is 0 or 1 provided that the total of p, q and r is 2 to 6; R<3> is H, alkyl of 1 to 6 carbons; phenyl or phenyl substituted by R<4>; or C1 to C4 alkylphenyl or C1 to C4 alkylphenyl in which the phenyl is substituted by R<4>; R<4>, R<5>, R<6> and R<7> are each independently selected from: (1) hydrogen; (2) alkyl having 1 to 6 carbon atoms; h