ANTAGONISTA DE WNT QUE COMPRENDE UN COMPONENTE DEL DOMINIO FRIZZLED Y UN DOMINIO FC; SECUENCIA DE ACIDOS NUCLEICOS QUE LO CODIFICA; COMPOSICION QUE LO COMPRENDE; Y SU USO PARA TRATAR TRASTORNOS DE PROLIFERACION CELULAR.

摘要

The present invention provides for chimeric Wnt antagonists comprising a Frz domain component derived from a Frizzled protein, a secreted Frizzled related protein or Ror protein and an Fc immunoglobulin component, and their use in the treatment and diagnostic detection of cellular Wnt signaling and Wnt-mediated disorders, including cancer.