| 摘要 |
PURPOSE:The titled stable drug composition obtained by freezing or lyophilizing human gamma type interferon useful as an antitumor agent in the presence of dextran and/or hydroxyethyl starch, not causing reduction in activity during the operation. CONSTITUTION:Human gamma type interferon (human IFN-gamma) having preferably 1X10<5>-1X10<7> international unit (IU)/mg specific activity and 1X10<2>-1X10<7>IU/ ml, especially 1X10<4>-1X10<7>IU/ml activity as an aqueous solution is blended with (A) preferably >=1mg, especially 3-50mg based on 1ml aqueous solution of IFN-gamma of dextran having preferably 10,000-100,000, especially 40,000-70,000 average molecular weight and/or hydroxyethyl starch having 10,000-200,000 especially 20,000-60,000, or 200,000 average molecular weight, and, if necessary, (B) preferably 10-50mg based on 1ml aqueous solution of IFN-gamma of sucrose, and the blend is frozen or lyophilized, to obtain a stable human IFN-gamma composition.
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