| 摘要 |
NEW MATERIAL:The compound of formula (R1 is H, lower alkyl or alkali metal; R2 is H or methyl). EXAMPLE:CK3A. USE:A physiologically active substance having cholesterol-lowering activity. PREPARATION:For example, a microbial strain belonging to Absidia genus or Circinella genus, e.g. Absidia cylindrospora (IFO 4000), Absidia glauca (IFO 4003), Circinella muscae (IFO 6410), etc. is cultured in the presence of monacolin K or an alkali metal salt of ML236B, at 20-30 deg.C for 4-7 days under shaking. |
