Aroyl benzofuran and benzothiophene acetic and propionic acids processes for their production and pharmaceutical compositions containing them.

摘要

Novel aroyl-substituted benzofuran and benzothiophene acetic and propionic acids of the formula: <CHEM> or a pharmaceutically acceptable salt wherein: R1 is hydrogen, hydroxy, C1-6 alkoxy, or methyl; R2 is hydrogen or methyl; R3 is hydrogen, C1-12 alkyl, phenyl, phenyl C1-6 alkyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, <CHEM> wherein the R groups are the same and are C1-6 alkyl; X1 is oxygen or is sulfur if R1 is hydrogen; X2 is oxygen or sulfur; Ar is phenyl unsubstituted or independently substituted with one or more substituents which are C1-6 alkyl, C1-6 alkoxy, halo, C1-6 alkyl sulfinyl, C1-6 alkyl sulfonyl, C1-6 alkyl thio, or 2-furyl, 3-furyl, 2-thienyl, or 3-thienyl; and the dotted line represents a single or double bond. These compounds are useful as analgesic, anti-inflammatory, and antipyretic agents.