| 摘要 |
NEW MATERIAL:A compound shown by the formula (R is alkyl). EXAMPLE:4-Acetyl-2-morpholinocarbonyl-6-trifluromethyl-furo[2,2-b]indole. USE:Having an analgesic and anti-inflammatory action, useful as a drug. PREPARATION:6-Trifluoromethyl-4H-furo[3,2-b]indole-2-carboxylic acid ester is hydrolyzed with an alkali such as NaOH, etc. to give a corresponding carboxylic acid, which is reacted with thionyl chloride, etc. to give a corresponding acid chloride, which is reacted with morpholine to give 2-morpholinocarbonyl-6-trifluoromethyl-4H-furo[3,2-b]indole. This compound is further reacted with an acid halide shown by the formula RCOX(X is halogen), to give a compound shown by the formula I . |
