| 摘要 |
The present invention relates to compositions, methods, kits and systems employing irradiation activated agents to improve or increase or prevent loss of toughness, work-to-fracture, post-yield toughness, fracture toughness and/or fatigue strength of a bone allograft on exposure to radiation. The irradiation activated agent can be an agent that increases crosslinking of collagen in bone during irradiation, for example ribose, 2-hydroxytetrahydropyran or ascorbate. |
| 主权项 |
1. A method of providing a bone allograft for use in a medical procedure comprising introducing a bone allograft in a container having disposed therein a composition comprising an irradiation activated agent, wherein the irradiation activated agent is in an amount effective to improve, or prevent or minimize loss of toughness, work-to-fracture, fracture toughness and/or fatigue strength on exposure of the bone allograft to radiation,
wherein said irradiation activated agent is ribose, wherein the container comprises an outer impermeable layer, an inner layer for receiving a solution comprising a solute and the irradiation activated agent, and a sealable opening, wherein the inner layer is porous to the solute and optionally porous to the irradiation activated agent, and wherein the container comprises a self-sealing valve and the composition is introduced into the container through the self-sealing valve after the container is sealed. |
