FURAN OR THIOPHENE DERIVATIVES

摘要

This invention relates to new compounds corresponding to the general formula: I R1 represents a C3-C10 cycloalkyl group substituted by C1-C6 alkyl radicals, a C3-C19-cycloalkyl-C1-C4 alkyl group which may be substituted by C1-C6 alkyl radicals, a C6-C8 bicycloalkyl group, a C6-C8 bicycloalkyl-C1-C4 alkyl group, a C6-C10 tricycloalkyl group, a C6-C10 tricycloalkyl-C1-C4 alkyl group, a C6-C9 tetracycloalkyl group or a C6-C9-tetracycloalkyl-C1-C4 alkyl group, R2 represents hydrogen, a C1-C6 alkyl group, a phenyl-C1-C4 alkyl group or a C1-C6 alkyl group which is substituted by halogen atoms, nitro groups, hydroxy groups, C2-C6 alkanoyloxy groups, C1-C4 alkoxy groups, C1-C4 alkoxy carbonyl groups or carboxy groups, R3 represented hydrogen, the 2-[5-(dimethylaminomethyl)-2-furyl-methylthio]-ethyl group, a C1-C18-alkyl group, a C3-C6-cycloalkyl group, a C3-C6-alkenyl group, a C3-C6-alkinyl group, an amino-C1-C4-alkyl group, a C2-C6-alkanoylamino-C1-C4-alkyl group, a mono-C1-C6-alkylamino-C1-C4-alkyl group, a di-C1-C6-alkylamino-C1-C4-alkyl group or a C1-C18-alkyl group, which is substituted by halogen atoms, nitro groups, hydroxy groups, C2-C6 alkanoyloxy groups, C1-C4 alkoxy groups, C1-C4 alkoxycarbonyl groups or carboxy groups, A represents a nitrogen atom or a methine group, B represents a cyano radical or a nitro group, and X represents an oxygen atom or a sulphur atom, and salts thereof. The compounds inhibit the secretion of gastric juice. Moreover, they have an ulcer-inhibiting and stomach-spasmolytic effect.