| 摘要 |
<p>NEW MATERIAL:A 2-amino-4-oxopyrrolo[2,3-d]pyrimidine-5-carboxylic acid shown by the formula I {X is -COR[R is -OR<1>(R<1> is H, or hydrocarbon residue), etc.]}, its amide, ester, and salt. EXAMPLE:2-Acetamino-3,7-dimethoxymethyl-4-oxopyrrolo[2,3-d]pyrimidine- 5-carboxylic acid. USE:A carcinostatic agent. Showing improved antitumor activity. Having antimicrobial action, useful as a remedy for microbism. PROCESS:A compound shown by the formula II (R<4> is group such as -CH2OH, -CHO, etc. capable of being converted into carboxyl groups; R<6> and R<8> are protecting group such as methoxymethyl, etc.; R<7> is protected amino such as acylamino, etc.) is oxidized with an oxidizing agent such as manganese dioxide, chromic acid, etc., and the protecting group of the carboxylic acid derivative is eliminated, to give a compound shown by the formula I (in case that R<1> is H).</p> |
