Biphenylylpropionic acid derivative, process for preparing the same and pharmaceutical composition containing the same.

摘要

Biphenylylpropionic acid derivatives of the formula: <CHEM> wherein R is an alkylcarbonyloxyalkyl group or an alkenylcarbonyloxyalkyl group having the formula: -@@-(CH2)m- O@R<2> wherein R<1> is hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms, R<2> is an alkyl group having 1 to 15 carbon atoms or an alkenyl group having 2 to 8 carbon atoms, and m is 0 or an integer of 1 provided that when R<1> is a lower alkyl group, m is 0, or a lactone having the formula: <CHEM> wherein R<3> and R<4> are hydrogen atom or a lower alkyl group having 1 to 2 carbon atoms, and n is an integer of 1 or 2. The compounds have excellent anti-inflammatory, analgesic and antipyretic activities. Moreover, the compounds have no irritation, rapid and long acting and high safety margin.