发明名称 A PROCESS FOR PREPARING ETHER AND THIOETHER MERCAPTOACYL PROLINE DERIVATIVES
摘要 <p>New mercaptoacyl derivatives of substituted prolines which have the general formula <IMAGE> or salts thereof may be used as hypotensive agents. In the formula X-R1 group is located at the 3- or 4- position of the proline ring; X is oxygen or sulfur; R is hydrogen or lower alkyl; R1 is lower alkyl, lower alkenyl, lower alkynyl, phenyl, substituted phenyl, phenyl-lower alkylene, or substituted phenyl-lower alkylene; R2 and R3 are independently selected from hydrogen, lower alkyl and trifluoromethyl; R4 is hydrogen, <IMAGE> or <IMAGE> R5 is lower alkyl, phenyl, or phenyl-lower alkylene; and n is 0, 1 or 2.</p>
申请公布号 IN152712(B) 申请公布日期 1984.03.17
申请号 IN1979DE52419 申请日期 1979.07.18
申请人 E.R.SQUIBB & SONS INC. 发明人 ONDETTI MIGUEL ANGEL;KRAPCHO JOHN
分类号 C07D207/04;A61K31/40;A61K31/401;A61P9/12;C07D207/10;C07D207/16;C07D207/22;C07D207/277;(IPC1-7):A61K27/00;C07D99/00 主分类号 C07D207/04
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