| 摘要 |
NEW MATERIAL:1-(2,3-Dimethyl-4-methoxyphenyl)-2-methyl-3-(1-pyrrolidinyl)-1- propanone of formula and its physiologically permissible acid addition salt. USE:A central muscle relaxant having improved action and durability, and effective to the remedy of spastic paralysis caused by cerebrovascular disturbance, wound of head, rachial injury, etc., and to the remission of myotonia in various diseases. PROCESS:The compound of formula can be prepared by reacting 1-(2,3-dimethyl- 4-methoxyphenyl)-1-propanone (a novel compound) with formaldehyde and pyrrolidine or its acid addition salt. The raw material used in the reaction can be produced by reacting 2,3-dimethylanisole with propionyl chloride in the presence of carbon disulfide and anhydrous aluminum chloride. |
