| 摘要 |
1478553 #-Alanine derivatives F HOFFMANN-LA ROCHE & CO AG 27 Aug 1975 [28 Aug 1974] 35358/75 Heading C2C [Also in Division C3] In the examples, compounds prepared are: #-alanine methyl ester hydrochloride is prepared by the esterification of #-alanine with methanol in hydrochloric acid, and converted to t-butyl- Oxycarbonyl - L - prolyl - # - alanine methyl ester on reaction with t-butyloxycarbonyl-L-proline, which is converted to t-butyloxycarbonyl-L-prolyl-#-alaninamide on treatment with ammonia, which yields L-prolyl-#-alaninamide on treatment with hydrogen chloride. Benzyloxycarbonyl - # - alaninamide was prepared by the action of ammonia on benzyloxycarbonyl-#-alanine, and converted to #-alaninamide by hydrogenation, which yields benzyloxycarbonyl - L - prolyl - # - alaninamide on reaction with benzyloxycarbonyl - L - prolyl - p - nitrophenyl ester, which gives L-prolyl-#-alaninamide on hydrogenation. Benzyloxycarbonyl - L - prolyl - # - alaninemethyl ester is prepared by the reaction of #- alanine methyl ester hydrochloride and benzyloxycarbonyl-L-proline, and yields L-prolyl-#- alanine methyl ester on hydrogenation. |
