发明名称 |
A PROCESS FOR PREPARING NICOTINONITRILES AND NICOTINAMIDES AND INTERMEDIATES USED THEREIN |
摘要 |
The invention resides in a process for preparing cardiotonically active 1,2-dihydro-6-(lower-alkyl)-2-oxo-5-(pyridinyl)nicotinonitriles (III) which comprises reacting a pyridinylmethyl lower-alkyl ketone (I) with tri-(lower-alkyl) orthoformate, acetic anhydride and acetic acid to produce 2-(lower-alkoxy)-1-(pyridinyl)ethenyl lower-alkyl ketone (II) and then reacting II with malononitrile in a lower-alkanol, where pyridinyl is 4- or 3-pyridinyl or 4- or 3-pyridinyl having one or two lower-alkyl substituents. |
申请公布号 |
ZA8303246(B) |
申请公布日期 |
1984.01.25 |
申请号 |
ZA19830003246 |
申请日期 |
1983.05.06 |
申请人 |
STERLING DRUG INC |
发明人 |
GELOTTE KARL OLAF;SINGH BALDEV |
分类号 |
A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4418;A61K31/455;A61P9/04;C07D213/50;C07D213/82;C07D213/85 |
主分类号 |
A61K31/4402 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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