POLYSILYLERAT KANAMYCIN A ELLER B SOM MELLANPRODUKT VID FRAMSTELLNING AV DERIVAT AV KANAMYCIN A OCH B

摘要

1-N-[ omega -amino- alpha -hydroxyalkanoyl] kanamycins A and B of the formula I in which R represents OH or NH2, are prepared by acylation of polysilylated kanamycin A or B, or polysilylated kanamycin A or B which has a protective group other than silyl on the 6'-amino group, with an acylating derivative of an acid of the formula II in which n is an integer from 0 to 2 and B is an amino protective group, in an essentially anhydrous organic solvent and by subsequent removal of all blocking groups. The compounds have therapeutic properties.