| 摘要 |
<p>An injectable rabies vaccine composition is disclosed which comprises a sterilized suspension of a minor concentration by weight of proteineous suckling mice or rat brain particles of injectable particle size laden with inactivated rabies virus in an aqueous buffer solution having a slightly basic pH-value and an amount, dissolved therein, of a buffer composition sufficient to stabilize the pH at said value, said buffer composition comprising a mixture of an organic base of the formula wherein R1 and R2 each are hydrogen or CH2CH2OH and an acid addition salt thereof, preferably a mixture of tris (hydroxymethyl)amino methane and its hydrochloride. Also a process for preparing said vaccine composition is disclosed. The vaccine composition exhibits a high potency and its pH value remains stable over a prolonged period of time.</p> |
