| 摘要 |
11-beta, 21-dihydroxy-16-alpha, 17-alpha-isopropylidene dioxy-9-alpha-halopregn-4-en-20-ones and 21-esters having anti-inflammatory and antirheumatic activity. M3A. Are new cpmds of formula (X = F, Cl, Br; R=H, lower acyl; A = H or Specific compounds include 11 beta, 21-dihydroxy -16 alpha, 17 alpha- isopropylidenedioxy-9 alpha-fluoropregn- 4-en-20-one and its 21-esters with acetic, propionic and hexanoic acids. Used as highly active topical anti-in flammatory agents; also antirheumatic agents about 16 times as active as prednisolone but with little or no catabolic activity, for oral or parenteral administration in usual formulations They are prepared as follows. |
