发明名称 |
NOVEL MONO- AND BISQUATERNARY AMMONIUM DERIVATIVES OF 2BETA, 16BETA-DIAMINO-5ALPHA-ANDROSTANE DERIVATIVES |
摘要 |
This invention relates to novel mono- and bisquaternary ammonium derivatives of 5 alpha -androstanes having the formula: <IMAGE> wherein: R1=H or alkyl (1-4 C); R2 and R3 each are alkyl (1-4 C) or form together with the N-atom a piperidino, pyrrolidino or morpholino group; R4=O or H( beta OR5) and R5=H or acyl derived from an organic carboxylic acid having 1-18, preferably 1-6 carbon atoms; the quaternarizing group being a saturated or unsaturated aliphatic hydrocarbon group having 1-4 carbon atoms the anion being halide; and acid addition salts of the monoquaternary compounds; and to pharmaceutical preparations containing one or more of said androstane compounds as active constituent. The compounds according to the invention are non-depolarizing neuromuscular blocking agents having very quick onset and recovery characteristics, a short duration of action and a favorable dissociation between muscle blocking and vagal blocking effects. |
申请公布号 |
AU8483882(A) |
申请公布日期 |
1982.12.23 |
申请号 |
AU19820084838 |
申请日期 |
1982.06.11 |
申请人 |
AKZO N.V. |
发明人 |
IAN CRAIG CARLYLE;DAVID SAMUEL SAVAGE;THOMAS SLEIGH |
分类号 |
A61K31/58;A61P21/02;A61P25/02;C07J1/00;C07J13/00;C07J21/00;C07J43/00;C07J71/00 |
主分类号 |
A61K31/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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