Novel amino carboxy alkyl derivatives of barbituric acid, preparation process and use for treating central nervous system disorders thereof

摘要

Therapeutically active amino, carboxy, alkyl derivatives of barbituric acid of formula (I) are disclosed, wherein at least one of R1, R2, R3 or R4 comprises an NH2 moiety and at least one of R1, R2, R3 or R4 comprises one COOH moiety and that R1, R2, R3 or R4 are as defined in the specification. Also disclosed is a method of preparing compounds of formula (I), and pharmaceutical compositions comprising the compounds. These compounds act as modulators of metabotropic glutamate receptors and, as such, are useful in treating diseases of the central nervous system related to the metabotropic glutamate receptor system.