| 摘要 |
NEW MATERIAL:The compound of formula I [R<1> is H or 1-5C alkyl; R<2>-R<4> are H, 1-5C alkoxy or OH; two of R<2>-R<4> may together form -O-CH2-O- or -O-CH2CH2-O-; m and n are 0-4; X is O, S, -N(R<5>)- (R<5> is H or 1-5C alkyl) or single bond; when m is 0, X is single bond; dotted line shows that the bond between the 4- and 5-carbon atoms of pyridazinone ring is single bond or double bond] or its salt. EXAMPLE:The compound of formula II. USE:A cardiotonic agent having high activity and excellent long-acting effect. PREPARATION:For example, a carboxylic acid of formula III is made to react with an alkyl halocarboxylate to obtain a mixed acid anhydride, which is reacted with an amine of formula IV.
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