摘要 |
4(3H)-quinazolinones of formula …<CHEM>… wherein… R1 and R3, independently from each other, represent a lower alkyl group;… R2 represents a lower alkoxycarbonyl group;… Q represents a phenyl group or a substituted phenyl group… R4 represents a hydrogen atom or a lower alkyl group;… R<5> represents a member selected from the group consisting of a hydrogen atom, lower alkyl groups, lower halogenoalkyl groups, lower alkenyl groups, (lower)alkoxy(lower)alkyl groups, hydroxy(lower)alkyl groups, (lower) alkylthio(lower)alkyl groups, (lower)alkylsulfinyl(lower) alkyl groups, (lower)alkylsulfonyl(lower)alkyl groups, di(lower)alkylamino(lower)alkyl groups, a benzyl group, a phenethyl group, pyridyl(lower)alkyl groups, furfuryl groups, a phenyl group, and substituted phenyl groups. …<??>Z1 and Z2, independently from each other, represent an oxygen or sulfur atom; and an acid addition salts thereof, are useful as hypotensive agents. There is also disclosed a process for the production of these derivatives and pharmaceutical compositions comprising said compounds. |