发明名称 DIPHENYLMETHANE DERIVATIVE PROCESS FOR ITS PREPARATION AND MEDICAMENTS CONTAINING IT
摘要 For the Contracting States : DE, FR, IT, NL, BE, CH, GB, SE, LI, LU) 1. 2,2'-Dihydroxy-5,5'-methylenedi-(p-toluene-sulphonic acid) and its salts. For the Contracting State : AT 1. Process for the preparation of 2,2'-dihydroxy-5,5'- methylenedi-(p-toluenesulphonic acid) and its salts, characterized in that a) m-cresol-6-sulphonic acid and/or its salts are reacted in an acid medium with formaldehyde and/or formaldehyde donors and, if desired, a resulting salt is converted into the free acid or into another salt, b) m-cresol-6-sulphonic acid and/or its salts are converted, in a basic medium, by means of form-aldehyde and/or formaldehyde donors into 4-hydroxymethyl-m- cresol-6-sulphonic acid and the latter is subjected in an acid medium to a condensation reaction with m-cresol-6-sulphonic acid and/or its salts and, if desired, a resulting salt is converted into the free acid or into a another salt, or c) m-cresol which is substituent in the 6-position by a detachable substituent is reacted, in an acid medium, with formaldehyde and/or formaldehyde donors to give a 5,5'-disubstituted 4,4'-dihydroxy-2,2'-dimethyl diphenylmethane, the substituents in the 5-position and 5'-position are split off and the product is sulphonated in an acid medium with sulphuric acid and/or an agent which splits off sulphonic acid groups and, if appropriate, a resulting salt is converted into the free acid or into another salt.
申请公布号 PT72160(B) 申请公布日期 1982.07.05
申请号 PT19800072160 申请日期 1980.12.04
申请人 BYK GULDEN LOMBERG CHEM FAB GMBH 发明人
分类号 A61K31/22;A61K31/185;A61K31/215;A61K31/255;A61P7/04;A61P17/00;C07C67/00;C07C301/00;C07C303/02;C07C303/06;C07C303/08;C07C303/22;C07C303/32;C07C309/30;C07C309/41;C07C309/42;C07C309/43;C07D295/02;C07D295/027;C07D295/03;C07D487/04 主分类号 A61K31/22
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