Whole cell enzyme composition containing fumed silica

摘要

A dimensionally stable glucose isomerase composition having improved hydraulic characteristics and suitable for continuous column isomerization of glucose to fructose is produced by incorporating a low density, high surface area silica such as fumed silica into wet whole microorganism cells, and extruding and drying the cells to obtain the cells in particulate form suitable for continuous column use. This technique is also applicable to microorganism cells containing other enzymes.