| 摘要 |
<p>New method for the preparation of N-aryl-N"(mono- or disubstituted)-urea derivatives having the general formula (I), (FORMULA) wherein aryl is an optionally substituted phenyl group, and R1 and R2 each stand for an optionally substituted alkyl, cycloalkyl, alkoxy or phenyl group, or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocyclic group which may contain a further hetero atom, or one of R1 and R2 may also stand for hydrogen, with the proviso that if one of R1 and R2 is an optionally substituted phenyl group, the other may represent only hydrogen atom or an optionally substituted alkyl or alkoxy group, by reacting a carbamate of the general formula (II) with an amine of the general formula (III), R1R2N-CO-X (II) Aryle-NH2 (III) or a carbamate of the general formula (IV) with an amine of the general formula (V), Aryle-NH-CO-X (IV) R1R2NH (V) wherein R1, R2 and aryl are as defined above and X is a lower alkoxy, phenoxy or substituted phenoxy group, in the presence of a tertiary amine catalyst. According to the invention a tertiary alkylamine containing altogether at least 6 carbon atoms and minimum one alkyl chain with at least 4 carbon atoms or a mixture of such tertiary alkylamines is applied as catalyst. </p> |
