| 摘要 |
The invention provides the novel chemical intermediate 4-(4-chlorophenyl)benzaldehyde, or the hydrate thereof; processes for its production and for its conversion to the known compounds 4-(4-chlorophenyl)-benzyl alcohol and 4-(4-chlorophenyl)benzyl chloride and bromide. These latter compounds are intermediates known for use in the manufacture of anti-arthritic benzyloxyacetic acids of the formula: <CHEM> in which Re is hydrogen or (1-4C)alkyl and Rf is (1-4C)alkyl or phenyl optionally bearing a halogeno substituent, and have previously only been obtainable by the use of potentially toxic chloromethyl ethers. The invention therefore also provides processes for the manufacture of the anti-arthritic acids of formula IV starting from 4-(4-chlorophenyl)benzaldehyde which avoid the use of such hazardous ethers. |
