发明名称 |
MOPROROL OPTICAL MESOTOMISM AND PHARMACETICAL COMPOSITION CONTAINING LEVOROTATORY MOPROROL ISOMER |
摘要 |
A process for the separation of moprolol having formula (I) into its two optical antipodes, by salifying racemic moprolol with L(+)glutamic acid; treating the thus obtained mixture of diastereoisomeric salts with a water/alcohol mixture, in this way separating the L(+)glutamate insoluble salt of (+)moprolol; treating the resultant mother liquors which contain in solution the L(+)glutamate sart of (-)moprolol with a base so as to separate the levorotatory isomer of crystalline moprolol, which finally undergoes a purification. …<??>Also a pharmaceutical composition containing said levorotatory isomer of …<CHEM>… |
申请公布号 |
JPS55149233(A) |
申请公布日期 |
1980.11.20 |
申请号 |
JP19800024201 |
申请日期 |
1980.02.29 |
申请人 |
SIEMENS SPA ITALIANA |
发明人 |
FERRARI GIORGIO;VECCHIETTI VITTORIO |
分类号 |
A61K31/13;A61K;A61K31/05;A61K31/135;A61P25/02;C07B31/00;C07B57/00;C07C39/06;C07C67/00;C07C213/00;C07C217/34 |
主分类号 |
A61K31/13 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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