Metabolic monitoring, a method and apparatus for indicating a health-related condition of a subject

摘要

An apparatus for indicating a health-related condition of a subject has an input interface for receiving a sequence of samples of a first biological quantity derived by a first measurement method, the first measurement method being an invasive measurement and having a first impact on the subject, and for receiving a sequence of samples of a second biological quantity derived by a second measurement method, the second measurement method being a non-invasive measurement and having a second impact on the subject, wherein the first biological quantity gives a more accurate indication of the health-related condition of the subject than the second biological quantity, wherein the first biological quantity and the second biological quantity have a correlation to the health-related condition of the subject, and wherein the second impact is smaller than the first impact; a predictor for providing, for a certain time, for which no sample for the first biological quantity exists, an estimated value of the first biological quantity using samples for the first biological quantity and, as far as available, samples for the second quantity; and an output interface for outputting the estimated value or data derived from the estimated value so that an indication for the health-related condition of the subject is obtained.

主权项

1. An apparatus for indicating a health-related condition of a subject, comprising:
an analytical device for sampling a biological quantity as part of a measurement method, where the biological quantity is related to the health-related condition of the subject; an input interface for receiving a raw sequence of samples of the biological quantity from the analytical device; a processor for processing the raw sequence of samples to obtain a processed sequence, the processor comprising an interpolator for providing data on an interpolated sample for a missing sample of the biological quantity using one or more samples at a preceding time instant or one or more samples at a subsequent time instant to obtain an interpolated sequence representing samples of the raw sequence and the interpolated sample; a low-pass filter for filtering the processed sequence to obtain a filtered sequence, the filtered sequence having a useful variation and a reduced non-useful variation compared to the processed sequence before filtering, wherein the low-pass filter has a cut-off frequency; a cut-off frequency calculator being arranged to determine the cut-off frequency of the low-pass filter, by:
for a plurality of different cut-off frequency values, low-pass filtering the samples of the raw sequence to obtain filtered test signals;for each filtered test signal, deriving a residual value based on the difference of the samples of the raw sequence and the filtered test signal to obtain a residual representation; andbased on the residual representation, determining the cut-off frequency of the low-pass filter adapted to the raw sequence of samples; and an output interface for processing the filtered sequence or for processing an enhanced sequence derived from the filtered sequence and for outputting an indication of the health-related condition of the subject based on the filtered sequence or the enhanced sequence derived from the filtered sequence.