FREMGANGSMAADE TIL FREMSTILLING AF 2- OG 6-SUBSTITUEREDE 1-CARBADETHIAPEN-2-EM-3-CARBOXYLSYRER OG MELLEMPRODUKTER TIL BRUG VED UDOEVELSE AF FREMGANGSMAADEN

摘要

Disclosed is a process for the total synthesis of 1-carbapenem antibiotics (I) from L-aspartic acid via intermediates II und III: wherein R is hydrogen, a pharmaceutically acceptable ester moiety or salt cation, or a readily removable blocking group; R<6> and R<7> are, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl; R<1> min is hydrogen or a protecting group; and R, R and R are independently selected from alkyl, aryl and aralkyl.