发明名称 |
PROCEDIMENTO PER LA PREPARAZIONE DI CEFALOSPORINE 3-SOSTITUITE EPRODOTTO OTTENUTO |
摘要 |
<p>There is described a process for preparing an enamine of formula (IX): <IMAGE> (IX) where R2 is a carboxylic acid protecting group and R3 is the residue of a carboxylic acid derived acyl group and where R5 and R6 are the same or different C1-4 alkyl or C7-10 aralkyl groups; or taken together with the adjacent nitrogen atom form a heterocyclic ring containing from 4 to 8 carbon atoms and optionally a further heteroatom selected from oxygen and nitrogen; by reacting a compound of formula (XII): <IMAGE> (XII) with an amine of formula HNR5R6, the reactant of formula (XII) being prepared by reaction of an appropriate enol derivative with a phosphorus reagent. The enamines of formula (IX) are useful in the preparation of 3-hydroxycephalosporins.</p> |
申请公布号 |
IT8048597(D0) |
申请公布日期 |
1980.05.06 |
申请号 |
IT19800048597 |
申请日期 |
1980.05.06 |
申请人 |
LILLY INDUSTRIES LIMITED |
发明人 |
JOHN ROYSTON CORFIELD;DEREK JOHNSON;CLIFFORD GORDON TAYLOR |
分类号 |
C07D501/08;C07D501/59;C07D513/04;C07F9/6561;(IPC1-7):A61K/ |
主分类号 |
C07D501/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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