发明名称 Antidepressant 4-alkylphenyl-piperidine cpds. - prepd. by catalytic hydrogenation of corresp. alcohol
摘要 <p>4-Phenylpiperidine derivs of formula (I) and their salts are new (where R3 is H or lower alkyl; Ph is p-phenylene opt. substd. by lower alkyl, lower alkoxy, NO2 and/or halogen; R2 is lower alkyl). (I) are antidepressants, e.g. acting as reserpine and tetrabenazine antagonists at doses of 3-30 mg/kg, noradrenaline uptake inhibitors at doses of 10-100 mg/kg, monoamine oxidase inhibitors at doses of 30-300 mg/kg, and 5-hydroxytryptamine potentiators at doses of 10-100 mg/kg (p.o). A typical cpd. is 4-(4-ethylphenyl)piperidine. In an example, this is prepd. by catalytic hydrogenation of 1- 4- (4-piperidyl)phenyl ethanol.</p>
申请公布号 NL7807554(A) 申请公布日期 1978.11.30
申请号 NL19780007554 申请日期 1978.07.13
申请人 CIBA-GEIGY A.G. TE BAZEL, ZWITSERLAND. 发明人
分类号 C07D211/12;C07D211/14;C07D211/16;C07D211/18;C07D211/22;C07D211/32;C07D211/52;C07D211/70;C07D211/74;C07D211/78;C07F3/02;(IPC1-7):07D211/08;61K31/445 主分类号 C07D211/12
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