INTERPHENYLENE 8-AZA-9-DIOXATHIA-11,12-SECOPROSTAGLANDINES UTILES COMME MEDICAMENTS

摘要

Interphenylene 8-aza-9-dioxothia-11,12-secoprostaglandins are prepared by the two-stage alkylation of the anion of a lower alkyl sulfonamide, R1SO2NH2, using first a compound of the formula: and second, a compound of the formula: The compounds produced have renal vasodilatory activity when administered orally and are therefore useful for treating patients with renal impairment.