Method for preparing human osteocalcin.

摘要

There is disclosed a method for preparing Gla<1><7> human osteocalcin and Glu<1><7> human osteocalcin or salts of these, which comprises introducing gamma -carboxyglutamic acid in a peptide synthetic method of human osteocalcin by use of a protected L- gamma -carboxyglutamic acid represented by the formula: wherein n represents 0, 1 or 2, or a salt thereof. n