| 摘要 |
<p>1398725 Disubstituted xanthone carboxylic acid compounds SYNTEX (USA) Inc 12 July 1972 [12 Jan 1972 5 June 1972] 47375/74 Divided out of 1398722 Heading C2C The invention comprises compounds of the formula wherein either the X groups are identical and are -SO 2 R groups where R is OH, NH 2 or mono - or di-(C 1 -C 6 )alkylamino; or one X group is C 1 -C 5 alkyl or alkoxy or C 3 -C 5 cycloalkyl or cycloalkoxy and the other X group is -SO 2 R as above; and non-toxic esters, amides and salts thereof. They may be obtained by treating a compound of one of the formulµ wherein R<SP>20</SP> is (C 1 -C 5 ) alkyl or alkoxy, or (C 3 -C 5 ) cycloalkyl or cycloalkoxy; with an inorganic base other than NH 3 or with NH 3 or a mono- or di-alkylamine; optionally converting the products into their non-toxic esters, amides or salts. Examples are given for the production of the compounds. Pharmaceutical compositions comprise the compounds of Formula I above which may be administered orally, topically, parenterally or by inhalation in conventional forms, optionally together with other pharmaceutical agents. They are useful for inhibiting the effects of allergic reactions, also as smooth muscle relaxants and as vasodilators.</p> |
