发明名称 |
4-(Polyalkoxyphenyl)-2-pyrrolidones |
摘要 |
4-(Polyalkoxyphenyl)-2-pyrrolidones of the formula <IMAGE> wherein R1 and R2 each are hydrocarbon of up to 18 carbon atoms or alkyl of 1-5 carbon atoms substituted by halogen, OH, COOH, alkoxy, alkoxycarbonyl, carboxamido or amino or collectively are alkylene of 1-3 carbon atoms, R3 is H or OCH3, R4 is H, alkyl, aryl or acyl and X is O or S possess neuropsychotropic activity. The compounds wherein X is O are produced by saponifying and decarboxylating a corresponding 2-pyrrolidone-3-carboxylic acid alkyl ester or cyclizing a corresponding 3-phenyl-4-aminobutyric acid or alkyl ester thereof. The pyrrolidones are converted to corresponding thiopyrrolidones in a conventional manner, e.g., by reaction with phosphorous pentasulfide in the presence of base.
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申请公布号 |
US4012495(A) |
申请公布日期 |
1977.03.15 |
申请号 |
US19750560193 |
申请日期 |
1975.03.20 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
SCHMIECHEN, RALPH;HOROWSKI, REINHARD;PALENSCHAT, DIETER;PASCHELKE, GERT;WACHTEL, HELMUT;KEHR, WOLFGANG |
分类号 |
A61K31/40;A61K31/4015;A61K31/4025;A61P25/18;C07C45/71;C07C47/575;C07D207/24;C07D207/26;C07D207/277;C07D317/00;C07D319/00;C07D333/00;C07D405/04;C07D405/12;C07D409/12;(IPC1-7):A61K31/40 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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