发明名称 |
AN ORTHO-LITHIATION PROCESS FOR THE SYNTHESIS OF 2-SUBSTITUTED-1-(TETRAZOL-5-YL) BENZENES |
摘要 |
A process utilizes the tetrazole functional group to direct lithiation at the ortho position of a phenyltetrazole and generate a nucleophilic aryllithium species which then undergoes reaction with an electrophile to generate a 2-substituted 1-(tetrazol-5-yl)benzene. The process is useful in the production of intermediates in the synthesis of angiotensin II antagonists. This novel process is a more cost effective and versatile route for the large-scale preparation of these key intermediates.
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申请公布号 |
CA2041620(A1) |
申请公布日期 |
1991.11.03 |
申请号 |
CA19912041620 |
申请日期 |
1991.05.01 |
申请人 |
MERCK & CO., INC. |
发明人 |
SHUMAN, RICHARD F.;KING, ANTHONY O.;ANDERSON, ROBERT K. |
分类号 |
A61K31/41;A61P43/00;C07D257/04;(IPC1-7):C07D257/04;C07F1/02;C07F7/10;C07F7/22 |
主分类号 |
A61K31/41 |
代理机构 |
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