| 摘要 |
<p>(A) Compds. (I):- where R1 = H or Me; R2 = 7-9 C aralkyl or aryl (opt. substd. by one or more methyl or 1-4 C alkoxy groups, Br or Cl); X Y = CH = (B) Acid addition salts of (I). Sedatives and neuroleptics; at high doses, antiserotonin and sympathicomimetic effects. 10 ml. N-phenylpiperazine added to 5 g. d-lysergic acid chloride hydrochloride in 200 ml. CH2Cl2 at 0 deg.C., the mixt. stirred 1 hr. at room temp., extd. between a soln. of Na2CO3 and CHCl3, the org. extd. dried, evapd., the residue mixed with Et2O and the insol. residue chromatographed on 240 g. SiO2 gel gave on elution with CHCl3 contng. 1.5-2.0% MeOH (I, R1 = H, R2 = Ph, X Y = CH = ), bimaleate m. 200 deg.C., (alpha)20D -20 deg. (C = 0.5, 50% alc.).</p> |
