发明名称 |
CRYSTALLINE 1-CARBACEPHALOSPORIN ANTIBIOTIC INTERMEDIATES |
摘要 |
<p>Crystalline p-nitrobenzyl 7 beta -phenoxyacetylamino-3-hydroxy-1-carba(dethia)-3-cephem-4-carboxylate and the crystalline mono-acetic acid solvate thereof are provided by mixing a carboxylic acid or a sulfonic acid with a solution of the 3-hydroxy ester in DMF or DMAC. Acetic acid provides the crystalline acetic acid solvate while other acids provide crystalline non-solvated 3-hydroxy ester. The crystalline forms are useful purified intermediates to antibiotics.</p> |
申请公布号 |
IL87697(A) |
申请公布日期 |
1993.04.04 |
申请号 |
IL19880087697 |
申请日期 |
1988.09.07 |
申请人 |
ELI LILLY AND COMPANY, INDIANAPOLIS, INC., U.S.A. |
发明人 |
|
分类号 |
C07D205/085;C07D463/00;(IPC1-7):C07D463/00 |
主分类号 |
C07D205/085 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|